Left Ventricular Phase Analysis and Outcomes of Cardiac Resynchronization Therapy
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- Category: Vol. 84, June 2016
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Left Ventricular Phase Analysis and Outcomes of Cardiac Resynchronization Therapy, WALID AHMED, WAEL SAMY, OSAMA TAYEH, NOHA BEHAIRY and ALIA ABD EL-FATTAH
Abstract
Background: Left ventricular dyssynchrony plays an important role in predicting response to Cardiac Resynchro-nization Therapy (CRT).
Methods: Thirty patients underwent CRT implantation. Assessment of Left Ventricular (LV) dyssynchrony was done through Gated Spect LV phase analysis.
Results: Thirty patients received CRT (mean age 58.7±9.0, 24 males). CRT implantation had a favorable prognosis on cardiac functions (LVEF pre-implantation: 26.8±4.7% versus 29.1±6.4% post-implantation; p=0.002). Reverse LV remod-eling (³15%) was documented in 19 patients. LV dyssynchrony parameters were correlated to LV reverse remodeling. Applying ROC curve for LV phase analysis showed that a cutoff 152º for histogram bandwidth had a sensitivity of 72.7% and specificity of 63.2% for predicting CRT non-response status. Also, a cutoff 54º for histogram standard deviation had a sensitivity of 81.8% and specificity of 63.2%.
Conclusion: Responders of CRT showed improved LV dyssynchrony profiles. Utilizing Gated SPECT LV analysis could provide predictors for CRT non-response.