Efficacy of Oxytocin Receptors Antagonist, Magnesium Sulfate and Calcium Channel Blockers in Treatment of Preterm Labour
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- Category: Vol. 84, June 2016
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Efficacy of Oxytocin Receptors Antagonist, Magnesium Sulfate and Calcium Channel Blockers in Treatment of Preterm Labour, SHERIN A. SHAZLY
Abstract
Objective: The purpose of this study is to compare between Atosiban acetate and magnesium sulphate and calcium channel blocker as short-term tocolytic agents for managing preterm labor.
Study desine: Randomized comparative single-blinded trial.
Methods: In this study, one hundred forty pregnant women were recruited. They were admitted with threatened preterm labor on attending the Obstetrics and Gynecology Emergency Department of Zagazig University Hospital (N=140). They divided into three groups, atosiban group 20 cases, nifedipine group 60 cases, magnesium sulfate group 60 cases, each group receive initial dose then maintenance dose till cessation of uterine contractions. We estimate pregnancy prolongation on 48 hours and 7 days and also the maternal and fetal side effects reported in each group.
Results: The result of the current study showed no signif-icant difference between the three groups as regard pregnancy prolongation but there is statistically significant difference between the three groups (p-value <0.05) as regards neonatal outcome except apnea and no statically difference as regard intrauterine fetal side effects and there is statistically significant difference between the three groups (p-value <0.05) for all maternal side effects except dyspnea and absence of symptoms.
Conclusion: We concluded that atosiban, magnesium sulphate, and nifedipine had the same efficacy in preventing preterm laboure with better patient compliance to nifedipine as it is oral drug and it had the least fetal and neonatal adverse effect.