Procalcitonin as a Marker of Infection in Patients with Liver Cirrhosis Compared to C-Reactive Protein
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- Category: Vol. 84, September 2016
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Procalcitonin as a Marker of Infection in Patients with Liver Cirrhosis Compared to C-Reactive Protein, NOUMAN EL-GAREM, AMANY SHOLKAMY, INAS F.K. MALATY, AMANY A. EL-KHOLY and MAHMOUD G. OMAR
Abstract
Background: Bacterial infections are a major cause of morbidity and mortality among patients with liver cirrhosis. Procalcitonin (PCT) is a prohormone that has been used as a marker for the diagnosis of bacterial infections. It may have a role in infections related to liver cirrhosis. The present study aims to evaluate the role of Procalcitonin as a marker of infection in patients with liver cirrhosis.
Patients and Methods: Plasma level of Procalcitonin was measured in 60 age and sex matched patients with liver cirrhosis (40 with clinical signs of infections and 20 without clinical signs of infections), and 15 healthy control subjects.
Results: At cut off point of 0.6ng/m1, the sensitivity, specificity, positive predictive value (+PV) and negative predictive value (—PV) of procalcitonin were 87.50%, 8333%, 85.7% and 85.4% respectively. Area under ROC Curve was 0.932. Area under ROC curve of procalcitonin was higher (0.932) than that of CRP (0.875). The sensitivity of procalcitonin was better than that of CRP with highly significant p-value <0.001.
Conclusions: Procalcitonin is a better useful marker in diagnosis of liver cirrhosis related infection rather than CRP.