Clinical Impact of the Expression of Th17-Associated Gene in Patients with Ulcerative Colitis
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- Category: Vol. 84, September 2016
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Clinical Impact of the Expression of Th17-Associated Gene in Patients with Ulcerative Colitis, MAGDY A. ELSERAFY, DINA S. ABDEL FATTAH, AHMED M. REFAAT and MOHAMMED A. MOHEY EL DIN
Abstract
Background: Ulcerative colitis (UC) is one of the two main entities of inflammatory bowel disease (IBD), the other being CroЬn's disease (CD). Several factors are involved in the pathogenesis of „BD including genetic susceptibility together with environmental factors that can disturb intestinal homeostasis, resulting in long standing repeated inflammation-remission cycles. Despite the differences between UC and CD, there are situations where a definite diagnosis cannot be made, such cases may be referred to as non-specific colitis. In later years. the concept of T helper 17 (Th17) cells has been introduced and it was shown that inflammation previously attributed to ТЫ could actually be Th17-driven and that these lymphocytes played an important role in IBD.
Aim of Work: To detect the expression of Th 17-assoсіаtед gene in patients with UC and determine their impact on clinical status of Egyptian patients with UC.
Patients and Methods: This is a cross sectional study that was conducted on 18 adult patients suffering UC referred to Gastrointestinal Endoscopy and Liver Unit. Twenty adult subjects were non IBD patients studied as case control. All subjects were submitted to complete medical history, clinical examination, laboratory investigations and colonoscopic evaluation.
Results: Тh17 associated gene does not show remarkable relation with either the UC disease severity or extent of extraintestinal manifestations.