Comparative Study between Different Doses of Ketorolac as an Adjuvant to Lidocaine in Intravenous Regional Anesthesia for the Upper Limb
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- Category: Vol. 84, September 2016
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Comparative Study between Different Doses of Ketorolac as an Adjuvant to Lidocaine in Intravenous Regional Anesthesia for the Upper Limb, MOHAMED ABOUL GHEIT, ASHRAF RADY, MAHA ISMAIL, REHAM MAGDY and HISHAM ZIADA
Abstract
Background: Regional anesthesia is being practiced safely with reduced risk. However, it is a limited technique due to lack of postoperative analgesia, time limit to surgical procedure and tourniquet pain.
Objectives: To compare the onset of sensory and motor blocks with adding different doses of Ketorolac to the Lidocaine in Intravenous Regional Anesthesia (IVRA) as a primary end point, hemodynamic changes as a secondary end point.
Study Design and Sample: This is a randomized double-blind controlled study which was conducted in the Departmeдt of Anesthesia, Kasr Al-Airy Teaching Hospital, Cairo University Egypt in the period between October 2013 and October 2015. Seventy six patients, aged 20-50 years, ASА I-II, both genders. scheduled for minor forearm and hand surgeries under IVRA were enrolled in the study.
Methods: The patients were randomly allocated into four equal groups: Group GL (п=19) received lidocaine in IVRA, group Gm10 (n=19) received lidocaine and Ketorolac 10mg mixture, group G0 (n=19) received lidocaine and ketorolac 20mg mixture and group GKr30 (n=19) received lidocaine and ketorolac 30mg. The onset of both sensory and motor blocks, hemodynamic (in the form of heart rate and blood pressure) were recorded.
Results: There was a statistically significant acceleration in the mean onsets of sensory and motor blocks in groups О lо, Giц20 and Gi~.30 compared to group GL (p<0.001). The results observed in the three groups were comparable. Also there was a decrease in both heart rate and mean blood pressure among the compared groups. Conclusion: The use of Kctorolac as an adjuvant to Lidocaine in IVRA resulted in significant acceleration of the onsets of both sensory and motor blocks, decrease in both heart rate and mean blood pressure among compared groups.