Trichloroacetic Acid Peel 15% + NB-UVB Versus Trichloroacetic Acid Peel 25% + NB-UVB for Stable Non-Segmental Vitiligo
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- Category: Vol. 84, September 2016
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Trichloroacetic Acid Peel 15% + NB-UVB Versus Trichloroacetic Acid Peel 25% + NB-UVB for Stable Non-Segmental Vitiligo, NAHLA S. HUNTER, HEBA M. MASHALY, DINA A. DORGHAM and SARAH I. ISMAIL
Abstract
Background: No single treatment proved to be satisfactory for vitiligo, therefore, dermatologists are still searching for innovative therapeutics and combinations.
Objectives: To evaluate the efficacy of combined trichloroacetic acid peel 15% (ТСА) +NB-UVB versus ТСА 25% + NB-UVB for cases with stable, non-segmental vitiligo.
Patients and Methods: Ten patients with stable, non-segmental and non-acral vitiligo were recruited. Two lesions per patient were treated: The 1st with ТСА 15% + NB-UVB, whereas, the 2пd with ТСА 25% + NB-UVB. Clinical assessment was done before and after treatment.
Results: The 1st lesions treated with ТСА 15% + NBUVB showed marked improvement in 70% of patients, moderate improvement in 10% and minimal response in 20%. While the 2пd treated lesions with ТСА 25% + NB-UVB revealed marked improvement in 20% of patients, moderate improvement in 40%, mild improvement in 10% and minimal in 30%. No koebneriation or disease activation has been reported
Conclusion: Initiation of vitiligo therapy with ТСА 15% can enhance the clinical response achieved by NB-UVB.
Recommendations: ТСА should be tried on a large scale of patients as monotherapy and combined therapy.