Value of CEA and CA19-9 as Diagnostic Markers for Cholangiocarcinoma
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- Category: Vol. 84, December 2016
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Value of CEA and CA19-9 as Diagnostic Markers for Cholangiocarcinoma, AYMAN Y. ABD EL REHIM, EMAN M. HASSAN, MOHAMMED S. ABD EL BARY, HANAN H. FOUAD, DINA O. HELMY, HESHAM M. EL MAKHZANGY and AHMED A. MOHAMMED
Abstract
Objective: Measurement of serum of CA 19-9 and CEA in patients with extrahepatic biliary strictures and their eval-uation as diagnostic markers in differentiating the malignant from the benign strictures, as compared to brush cytology and its correlation with laboratory variables and the stage of the disease after 6 months of follow-up.
Methods: The study is a cross sectional study including 60 patients presented to endoscopic retrograde cholangiopan-creatography (ERCP) unit with extrahepatic biliary obstruction. Brush cytology was taken from the site of stricture, serum samples were collected for measurement of CA 19-9 and CEA. Upon the results of brush cytology, patients were grouped as follows: Group A including 29 patients with malignant extrahepatic strictures, Group B 27 patients with benign extrahepatic strictures (as 4 patients were excluded due to unsatisfactory cytology sample).
Results: Showed significantly higher levels of serum CA19-9 and CEA in the malignant group compared to the benign group (p-value<0.001) with sensitivity of CA 19-9 80%, and CEA 82% and, the specificity of CA19-9 was 65% and was 50% for CEA.
Conclusion: Both CA19-9 and CEA are useful reliable diagnostic tests in differentiating extrahepatic CCA from benign biliary obstruction.