The Enhancement Effect of Mesenchymal Stem Cells on Nephrotoxicity Induced by Cisplatin in Albino Rats
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- Category: Vol. 84, December 2016
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The Enhancement Effect of Mesenchymal Stem Cells on Nephrotoxicity Induced by Cisplatin in Albino Rats, MOHAMED ABD EL-AZIZ, LAILA RASHED, SALWA FAYEZ, WALAA IBRAHIM and ENGY MEDHAT
Abstract
Background: Cisplatin is one of the most effective and potent anticancer drugs. It is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side effects such as nephrotoxicity. Bone marrow derived mesenchymal stem cells (MSCs) have shown great potential in cell therapy of solid organs.
Methods: This work included thirty rats which were divided equally into three groups: Healthy control group, nephrotoxicity group induced by cisplatin, nephrotoxicity group received MSCs. Serum levels of tumor necrosis factor alpha (TNF a) by ELISA and serum levels of urea and crea-tinine by colorimetry were performed in all groups.
Results: Serum levels of TNF a, urea and creatinine were decreased in the treated group compared to the diseased group
Conclusion: Administration of MSCs improves nephro-toxicity as evidenced by the biochemical marker of inflam-mation (TNF a) and kidney function tests.