Relation of Aquaporin 3 Expression to Skin Aging in Egyptian Population; Immunohistochemical Study
/ 0
- Details
- Category: Vol. 84, December 2016
- Hits: 456
Relation of Aquaporin 3 Expression to Skin Aging in Egyptian Population; Immunohistochemical Study, SHAHIRA A. AMADAN, OLA M. ABU ZEID, NEVINE A. DORGHAM, HEBA M. MASHALY, MAGDA I. ASSAF and MARWA A. AMER
Abstract
Background: AQP3 is a water channel protein concerned with glycerol and water transport in the skin. It is also involved in several physiological processes in the skin including skin hydration, proliferation and wound healing.
Aim of Work: The current study aimed at examination of AQP3 pattern and expression in healthy non sun exposed skin in selected sample of Egyptian population. This was to asses if AQP3 shows changes with age and can be involved in skin aging in Egyptian population.
Patients and Methods: This study included twenty healthy controls. Each patient was subjected to short medical history and cutaneous examination. Skin biopsies were examined and immunohistochemical study was done using anti aquaporin 3 antibodies.
Results: AQP3 stained the epidermis in both the basal and spinous layers. No staining reaction was detected within the stratum corneum. There was no statistical significant correlation of AQP3 expression among healthy subjects as regards the age and gender.
Conclusion: AQP3 expression didn’t show significant difference with age in the studied sample of Egyptian popu-lation in contrast to previous studies conducted in other countries denoting that genetic factors and/or skin phenotype may affect AQP3 expression.