Expression of Aquaporin 3 in the Skin of Psoriatic Patients in Egyptian Population; Immunohistochemical Study
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- Category: Vol. 84, December 2016
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Expression of Aquaporin 3 in the Skin of Psoriatic Patients in Egyptian Population; Immunohistochemical Study, SHAHIRA A. RAMADAN, OLA M. ABU ZEID, NEVINE A. DORGHAM, HEBA M. MASHALY, MAGDA I. ASSAF and MARWA A. AMER
Abstract
Background: Aquaporin 3 (AQP3) is a glycerol water channel that is involved in water transport and hydration of the epidermis, in the regulation of keratinocytes proliferation, cell migration, and tumorigenesis.
Objectives: Examination of AQP3 expression in psoriatic epidermis compared to healthy controls to asses if it can be related to the complex pathogenesis and severity of the disease.
Patients and Methods: This study included forty patients with psoriasis and twenty healthy, age and sex matched, controls. Skin biopsies from cases and controls were examined and immunohistochemical study was done using anti aquaporin 3 antibodies.
Results: Among psoriasis patients, the cytoplasmic ex-pression of AQP3 was significantly higher than control (p-value = <0.001). On the other hand, there was no significant difference between patients and controls as regards the mem-branous expression of AQP3 in all layers of the epidermis.
Conclusion: In psoriasis, the abnormal cytoplasmic loca-tion of AQP3 may affect its function and lead to dryness of the lesion. The high expression of AQP3 can be related to hyperproliferation of the epidermis and increased T cell traficking seen in psoriasis.