Effect of Exercise on the Interplay between Serum Irisin and Some Metabolic and Hemostatic Parameters in Obesity Rat Model
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- Category: Vol. 85, September 2017
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Effect of Exercise on the Interplay between Serum Irisin and Some Metabolic and Hemostatic Parameters in Obesity Rat Model, DALIA I. ABD AL-ALEEM and SUZAN M.M. MOURSI
Abstract
Background: Abnormalities in coagulation and hemostasis represent a well-known link between obesity and thrombosis. Irisin is a novel myokine and adipocytokine. There are appar-ently contradictory reports concerning irisin levels and their correlation with obesity-related parameters. Moreover, the effect of exercise training on irisin level remains controversial.
Objective: This study was designed to investigate irisin level in case of high fat diet induced obesity in rats and to evaluate effect of chronic exercise training on this level in relation to some metabolic and hemostatic parameters.
Material and Methods: Thirty adult male albino rats were equally divided to 3 groups, group (1): Control group, group (II): High Fat Diet (HFD) fed group for 8 weeks (58% fat) and group (III): High fat diet fed group and exposed to a moderate exercise training protocol (swimming for 90min/day for 5 days weekly) for 8 weeks. In all groups, BMI, Abdominal Circumference (AC), serum levels of irisin, glucose, insulin, HOMA-IR, lipid profile parameters, TNF-a, MDA, plasma fibrinogen and d-dimers levels were measured and Bleeding Time (BT), Whole Blood Clotting Time (WBCT), PT, aPTT were also evaluated.
Results: The present study revealed that HFD for 8 weeks significantly increased BMI, AC, serum glucose, insulin, Total Cholesterol (TC), Triglycerides (TG), Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), TNF-a, Malondialdehyde (MDA) levels and HOMA-IR, plasma fibrinogen and d-dimers levels. Furthermore, there was a significant reduction in serum irisin level in the same group (group II), with a significant negative correlation between this hormone and all the above mentioned parameters, except, there was a significant positive correlation with the decreased levels of High Density Lipoproteins (HDL). Further, there was a significant reduction in BT, WBCT, PT, aPTT (with a significant positive correlation versus serum irisin level). However, exercise training in group III produced a significant increase in serum irisin level and marked improve-ment in the above mentioned metabolic and hemostatic pa-rameters with the preservation of the same type of correlations versus serum irisin level in the exercising group.
Conclusion: Elevated irisin levels by chronic exercise training may play a role in improving the metabolic and hemostatic abnormalities associated with obesity in rats.