Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Patients Undergoing Spinal Surgery
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- Category: Vol. 85, September 2017
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Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Patients Undergoing Spinal Surgery, TAREK M. RADWAN, MOHAMMD W. AWAD, SAFINAZ H. OSMAN, HANI M. EL-KADI and MOHAMMED A. FAISAL
Abstract
Background: Dexmedetomidine, a potent selective a2- adrenergic agonist, produces sedation and analgesia. This study was conducted to assess the effect of dexmedetomidine infusion on sevoflurane requirements, recovery profiles, and emergence agitation in patients undergoing spinal surgery.
Our study aimed to comparet minimal alveolar concen-tration (MAC) of sevoflurane required to achieve same depth of anaesthesia measured by the bispectral index (BIS) in patients undergoing spinal surgeries using sevoflurane anaes-thesia only versus combined sevoflurane and dexameditomi-dine as well as comparing recovery time and hemodynamic stability.
Methods: Patient was randomly allocated to one of two groups using odd and even number:
•Group I (Dexmedetomidine group) (33 patients) Receiving dexmedetomidine and sevoflurane.
•Group II (Control group) (33 patients) Receiving Sevoflurane.
Evaluated variable included mean sevoflurane concentra-tion, mean BIS values and Intraoperative mean arterial blood pressure.
Results: MAC of sevoflurane of Dexmedetomidine Group was reduced by 58.1-75% compared to Control Group, Dexme-detomidine infusion decreased haemodynamic responses to various noxious stimuli and attenuated the emergence from anaesthesia by decreasing the immediate haemodynamic response as regard mean arterial blood pressure, and heart rate.
Conclusion: We conclude that the continuous infusion of dexmedetomidine, as adjuvant in general anesthesia, signifi-cantly decreases the requirement of sevoflurane for maintaining adequate depth of anesthesia.