The Association between Serum Lipocalin-2 and the Inflammatory Condition in Migraine Patients
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- Category: Vol. 85, September 2017
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The Association between Serum Lipocalin-2 and the Inflammatory Condition in Migraine Patients, NANEES F. EL-MALKEY, WESAM M. REDA ASHOUR, WALID M. REDA ASHOUR and TAMER S. EL-SERAFY
Abstract
Background: Migraine is considered a disabling neurovas-cular disorder. The exact pathophysiological mechanism underlying migraine headache is still incompletely understood. Activation of meningeal afferents, neuopeptide release and neurogenic inflammation play a pivotal role in the generation of pain in migraine headache. Lipocalin-2 (LCN2), a secretory protein, regulates diverse cellular processes such as cell death/survival, inflammation and tissue regeneration. LCN2 is also secreted by brain astrocytes under inflammatory condi-tions and promotes apoptosis, morphological changes and migra-tion in astrocytes both in vitro and in vivo and acts as a proinflam-matory mediator in the central nervous system.
Aim: To assess the serum level of LCN2 in migraine patients and its asso-ciation with the systemic inflammatory mediators.
Subjects and Methods: This study was conducted during the period between March, 2016 and November, 2016 in Outpatient Clinics of Zagazig University Hospitals on 60 age-weight matched individuals. They were divided into 2 equal subgroups. Group (I): Control without headache and group (II): Was further subdivided into 2 groups; group (IIa): Mi-graine patients without aura (MWoA) and group (IIb): Migraine patients with aura (MWA). For each group, serum LCN2, C-Reactive Protein (CRP), Tumor Necrosis Factor-a (TNF-a), bilirubin, Triglyceride (TG), High Density Lipoprotein-Cholesterol (HDL-c) and Atherogenic Index of Plasma (AIP) were measured.
Results: In group IIa (MWoA): LCN2, CRP and TNF-a levels were significantly higher than that of group I, while total bilirubin and direct bilirubin were significantly lower than that of group I. In group IIb (MWA): LCN2, CRP, TNF-a, TG levels and AIP value were significantly higher than that of group I and IIa, while total bilirubin and direct bilirubin were significantly lower than that of group I and IIa. However, there was a non-significant difference in serum HDL-c between groups.