Serum Magnesium and Cardiovascular Complications in Hemodialysis Chronic Renal Failure Patients
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- Category: Vol. 85, September 2017
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Serum Magnesium and Cardiovascular Complications in Hemodialysis Chronic Renal Failure Patients, MAHMOUD R. MOHAMED, MAHMOUD H. KHEDR and MANAR S. MOHAMED
Abstract
Background: Chronic Kidney Disease (CKD) is kidney damage for 3 months as defined by structural or functional abnormalities of the kidney, manifest by either: Pathological abnormalities; or markers of kidney damage, GFR <60ml/min/ 1.73m2 for 3 months. In addition, electrolyte disturbance involving hypocalcaemia, hyperphosphatemia and hyperma-gnesaemia.
Aim of the Study: To determine the correlation between serum magnesium and development of cardiovascular com-plications in ESRD on hemodialysis, assessed by measuring common Carotid Intima Media Thickness (CIMT), Left Ven-tricular Hypertrophy (LVH) and peripheral vascular calcifica-tion.
Patients and Methods: Present study was conducted on sixty-eight end stage renal failure patients on maintenance hemodialysis. Age range: 18-76 years old, 32 males, 36 females, recruited from the renal and Dialysis Unit, Department of Internal Medicine, El-Minya University Hospitals, Egypt from 2015 to 2016. We measure kidney function test. CBC, serum electrolyte: Magnesium (Mg), Calcium (Ca), Phosphorus (P), sodium (Na) and potassium (K). Serum intact Parathyroid Hormone (iPTH) lipid profile: Total Cholesterol (TC), Trig-lycerides (TG), LDL, HDL. Carotid artery duplex: (CIMT). Peripheral vascular Doppler: Peripheral vascular calcification, Echocardiography and ECG.
Results: Serum (Mg) level ranges from 1.3mg/dl to 4mg/dl with mean value of (Mg) 2.6±0.5. There was a significant negative correlation between serum (Mg) level and the average (CIMT) of both sides. There is non-significant negative correlation between serum (Mg) level and {(LVH) (r=–0.10 with p>0.05), Parathyroid Hormone (PTH) (r=–0.09 with p >0.05), total cholesterol (r=–0.01 with p>0.05), (TG) (r=–0.03 with p>0.05), Low-Density Lipoprotein (LDL) (r=–0.03 with p>0.05) and duration of dialysis}. There is no relation between serum (Mg) and sex of the patients. Also no significant relation between serum (Mg) and different degree of calcification. There is non-significant positive correlation between serum (Mg) level and High-Density Lipoprotein (HDL) (r=0.07 with p>0.05).