The Effect of Vitamin E Administration on Induced Osteoporosis in Adult Female Albino Rats
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- Category: Vol. 85, September 2017
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The Effect of Vitamin E Administration on Induced Osteoporosis in Adult Female Albino Rats, SAMEH SOLTAN, HAREDY HASSAN HAREDY and ESSSAM OMAR KAMEL
Abstract
Background: Osteoporosis, a major public health problem, is becoming increasingly prevalent with the aging of the world population.
Objective: This study aimed to evaluate the effect of Vitamin E administration on the induced osteoporosis in female albino rats.
Material and Methods: Sixty two adult female albino rats were divided into 5 groups. GI: 14 rats were kept as normal control group, GII: 8 rats were exposed to a sham operation and received placebo, GIII: 8 rats were exposed to a sham operation and got Vitamin E administration. GIV: 16 rats underwent ovariectomy operation with no treatment and G V: 16 rats underwent ovariectomy with Vitamin E adminis-tration.
Results: Only in Group IV, which did not take Vitamin E, and underwent ovariectomy, had alteration in the histo-pathological findings in the form of thinned trabeculae, less cellularity and excess amount of bone marrow compared to Group V, which were ovariectomized and got Vitamin E. This was in addition to elevation of alkaline phosphatase in bone and serum with decrease in seum rankl as a marker of improv-ing of osteoporosis.
Conclusion: Vitamin E has showen therapeutic effect against osteoporosis especially that occurred in females in the post-menopausal period. RANKL was found to be a useful marker for detecting the state of osteoporosis, when compared with other laboratory results and histological findings. It can be used in the detection of osteoporosis as it is cheap, easily applicable and still accurate rather than other tests like DEXA scan which is expensive.