Effect of Various Donor Risk Factors on Graft and Patient Survival in Living Donor Liver Transplantation
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- Category: Vol. 85, December 2017
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Effect of Various Donor Risk Factors on Graft and Patient Survival in Living Donor Liver Transplantation, SHERIF M. MOGAWER, MONA A. HEGAZY, ALI H. FARAG, OMAR A. ASHOUSH and MOSTAFA A. EL-SHAZLY
Abstract
Background: Liver transplantation is an established. effective and often lifesaving treatment for acute and chronic end stage liver disease. Risk factors in donors should be characterized and thoroughly studied in order not to compromise the procedure of transplantation and also not to lose donors who may be considered unideal yet, still can be candidates for transplantation.
Objectives: The objective is to evaluate the effect of variable donor risk factors on the outcome of LDLT regarding the morbidity and mortality.
Methods: Our study which included a cohort of 48 patients who underwent living donor liver transplantation for ESLD caused by chronic HCV. Morbidity and mortality were assessed a three and twelve months. Data obtained studied in correlation with various donor related risk factors.
Results: We observed increased rates of graft rejection and recipient mortality when these risk factors were present: Advanced donor age, donor obesity, donor-recipient gender mismatch.
Conclusion: The donor age, sex match, Body Mass Index (HMI), are donor risk factors that had a high impact on recipient mortality and graft rejection.
Key Words: Transplant — HCV genotype 4—Donor risk factors.