Effect of GERD on the Larynx: Evidence from Immunohistochemical Test and Spirometry
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- Category: Vol. 85, December 2017
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Effect of GERD on the Larynx: Evidence from Immunohistochemical Test and Spirometry, MOHAMMED R. ABD EL-HADY, YOSSRA A. SALLAM, EMAN S. MOHAMMED and ABDULLAH M. GAMAL
Abstract
Background: Gastroesophgeal reflux is defined as the passage of refluxed gastric contents into esophagus and oro-pharynx. The cause and effect relationship between GERD and laryngeal signs and symptoms is far from being established, despite the fact that some laryngeal symptoms may improve in response to acid suppression.
Aim of the Work: This work is designed to study the effect of GERD on the larynx using both histochemical and functional objective measures.
Subjects and Methods: This cross sectional study was conducted on 30 patients suffering from GERD with persistent laryngeal symptoms. The diagnosis of GERD was established using double probe PH manometry and upper gastro-intestinal endoscope. All patients underwent spirometry and flexible laryngoscope. Laryngeal findings included posterior laryngitis, contact granuloma, interarytenoid pachydermia, vocal fold polyp, Reinke's edema and cancer larynx. Patients with laryn-geal masses (6 patients) underwent direct laryngoscope and immunohistochemical test was done to the obtained biopsies.
Results: Helicobacter pylori antibodies were present in 5 specimens and spirometry was impaired in 13 patients.