Advances in Drug Delivery Systems: Improving Efficacy and Patient Compliance
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- Category: Vol. 85, December 2017
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Advances in Drug Delivery Systems: Improving Efficacy and Patient Compliance
Abstract
Background: Drug delivery systems (DDS) play a pivotal role in optimizing therapeutic efficacy by influencing the Ab-sorption, Distribution, Metabolism, and Excretion (ADME) of drug compounds. These systems aim to enhance drug bioavail-ability, reduce adverse effects, and improve patient compliance. Aim of Work: This review explores the diverse range of drug delivery systems and their impact on drug pharmacokinet-ics and pharmacodynamics. It investigates the advantages and challenges associated with different delivery methods and their role in advancing therapeutic outcomes. Methods: A comprehensive literature review was conduct-ed to examine existing research on drug delivery systems. This included exploring various delivery methods, their underlying principles, and their applications in different therapeutic areas. Results: Drug delivery systems have evolved signifi-cantly to address the limitations of traditional dosage forms. Techniques such as amorphous solid dispersion, liposomes, and complexation have been instrumental in enhancing the oral bioavailability of poorly soluble drugs. Modified release (MR) formulations, including sustained-release and controlled-release systems, have improved patient compliance and thera-peutic outcomes by reducing dosing frequency and minimizing adverse effects. Moreover, the development of long-acting re-lease (LAR) formulations has showcased the potential for ex-tended drug action, particularly in areas like contraception and hormone replacement therapy. Targeted drug delivery systems have gained prominence in oncology, enabling the delivery of therapeutic agents directly to cancer cells, thereby minimizing systemic toxicity. Additionally, efforts to prolong drug circula-tion and delay clearance have led to the development of drug delivery systems that enhance drug residence time in the body. Conclusion: Drug delivery systems have become an inte-gral part of pharmaceutical development, offering innovative solutions to address challenges in drug delivery and improve patient care. While these systems have shown significant prom-ise, their successful implementation requires a multidiscipli-nary approach involving pharmaceutical scientists, clinicians, and engineers. Future research should focus on developing more sophisticated and personalized drug delivery systems to meet the evolving needs of patients.