Correlation between Uterine Artery Diastolic Notch, Serum Human Chorionic Gonadotropin and Severity of Preeclampsia
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- Category: Vol. 85, March 2017
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Correlation between Uterine Artery Diastolic Notch, Serum Human Chorionic Gonadotropin and Severity of Preeclampsia, ZAINAB S. IBRAHIM, MOHMMED K. ALLOUSH, MOHMMED ABD EL-HADY and AHMD M. SADEK
Abstract
Background: Early midtrimester measuring of plasma levels of Human Chorionic Gonadotropin (HCG) is recom-mended because of its predictive value of diagnosing pre-eclampsia and its severity. Uterine artery Doppler studies also are recommended to be performed between 22-26 weeks' gestation as it increases the predictive value for adverse pregnancy outcomes including preeclampsia and/or IUGR.
Aim of Study: Determine the correlation between uterine artery Doppler diastolic notch, serum human chorionic gona-dotropin and severity of preeclampsia.
Patients and Methods: One hundred twenty pregnant women are classified in to three groups, Group one consists of 40 women with normal pregnancy, Group 2 consists of 40 patients with mild pre-eclampsia and Group 3 consists of 40 patients with sever pre-eclampsia and followed-up between 20-36 weeks' gestation regularly every 4 weeks until 28 weeks gestation then every two weeks until 36 weeks with measuring plasms HCG level during early midtrimester and uterine artery Doppler studies between 22-26 week'gestation.
Result: The level of maternal serum HCG of normal control group is found to be the lower followed by mild group then sever group and the difference is found to be statistically highly significant (p<0.001). In addition to, the uterine artery Doppler S/D ratio and RI in the control group is found to be lower in normal control group followed by mild then sever group.
Conclusion: There is strong positive correlation between the level of maternal serum HCG, uterine artery Doppler indices and severity of pre-eclampsia.
Recommendation: We recommend to measure HCG level in addition to performance uterine artery Doppler studies for prediction of severity of pre-eclampsia.