Effects of Statins Versus Corticosteroid and their Combination on the Modulation of Acute Lung Injury in Rats: Comparative Study
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- Category: Vol. 85, March 2017
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Effects of Statins Versus Corticosteroid and their Combination on the Modulation of Acute Lung Injury in Rats: Comparative Study, SOHEIR A. ABD EL-WAHED, EMAN A. ABD EL-RASHID, OLFAT G. SHAKER, MARIAN Y. WISSA, MARY E. ATTIA and EMAD EL-MAHDI
Abstract
Background: Acute Lung Injury (ALI) is an extremely important health problem. It affects all age groups and has a high mortality up to 30-50%. The pleiotropic properties of statins, including anti-inflammatory, immuno-modulatory and anti-oxidant effects could be promising in the treatment of ALI.
Aim of the Work: The aim of the present work was to compare the effect of statins versus corticosteroid and their combination in the modulation of ALI.
Methods: 162 male albino rats were subdivided into normal group, Lipopolysaccharide (LPS) treated rats (model of ALI), saline treated groups, ALI statins (simvastatin, rosuvastatin) treated groups, ALI methylprednisolone treated group, and ALI combination therapy of statins and methyl-prednisolone. Lung tissue myeloperoxidase, malondialdehyde, and total lung proteins were assessed at 24 hours, 72 hours and on the 7th day after induction of ALI. Histopathological examination of the left lungs of all animals in all groups was done all through the experimental periods.
Results: The lipopolysaccharide induced ALI group showed significant increase in myeloperoxidase, malondial-dehyde, total lung proteins and pathological score. Treatment of rats with ALI with statins or methylprednisolone resulted in significant decrease in these elevated parameters at 24 hours, 72 hours and on the 7th day as compared to the untreated model group. Methylprednisolone therapy alone was signifi-cantly effective than simvastatin therapy alone in reducing myeloperoxidase, malondialdehyde, total lung proteins and pathological score. Rosuvastatin was more significantly effective in reducing the level of myeloperoxidase, malondi-aldehyde, total lung proteins and histopathological score measured at the end of the present study than simvastatin therapy. Regarding the combination therapy, methylpredniso-lone with rosuvastatin showed the most significant reduction of all parameters all through the experiment.
Conclusion: A significant improvement and amelioration of ALI biochemical and pathological changes could be achieved