Potential Therapeutic Role of Rosuvastatin and Simvastatin in Acute Lung Injury (Experimental Study)
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- Category: Vol. 85, March 2017
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Potential Therapeutic Role of Rosuvastatin and Simvastatin in Acute Lung Injury (Experimental Study), SOHEIR A. ABD EL-WAHED, EMAN A. ABD EL-RASHID, OLFAT G. SHAKER, MARIAN Y. WISSA and MARY E. ATTIA
Abstract
Background and Aim: Acute Lung Injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure. Simvastatin and rosuvastatin are a well established class of drugs that effectively decrease serum cholesterol levels. The present work was designed to study the potential therapeutic role of simvastatin and rosuv-astatin, in an experimental model of ALI in rats.
Methods: 90 male wister rats were subdivided into normal group, Lipopolysaccharide (LPS) treated rats (model of ALI), saline treated group, ALI + simvastatin treated group, ALI + rosuvastatin treated group. Lung tissue TNFa, IL-1b were assessed at 24 hours, 72 hours and on the 7th day after induction of ALI. Serum AST, ALT, creatinine phosphokinase, creatinine were assessed at the end of the experiment. The effects of simvastatin and rosuvastatin treatment on the ach induced contractions of tracheal rings isolated from rats with ALI were studied.
Results: The LPS induced ALI group showed significant increase in TNFa and IL- 1b. Treatment of rats with ALI with simvastatin, rosuvastatin resulted in significant decrease in these elevated parameter at 24 hours, 72 hours and on the 7th day as compared to the untreated model group. Rosuvastatin was more significantly effective in reducing TNFa, IL-1b at the end of the present study than simvastatin therapy. Moreover rosuvastatin therapy in ALI did not significantly affect AST, ALT, serum creatinine, or creatinine kinase. Simvastatin and rosuvastatin decreased significantly the ach induced contractile responses of the isolated tracheal rings when compared to the untreated model group.
Conclusions: Simvastatin or rosuvastatin therapy could be beneficial in management of ALI. Rosuvastatin was more safe than simvastatin. These results could offer a new oppor-tunity in management of ALI.