Role of Helicobacter Pylori in Patients with Cancer Colon and Colonic Polyps
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- Category: Vol. 85, March 2017
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Role of Helicobacter Pylori in Patients with Cancer Colon and Colonic Polyps, AHMED YAKOOT, TALAAT FATHY and SAMEH M. ABDELMONEM
Abstract
Background and Study Aim: Current gastric H. pylori infection is associated with an increased risk of colorectal polyps in African-Americans patients with H. pylori induced gastritis may benefit from early screening colonoscopy as a preventative measure for colorectal cancer. The work aimed to study the role of Helicobacter pylori in patients with cancer colon and colonic polyps admitted to the Tropical Medicine Department, Faculty of Medicine, Zagazig University (inpa-tients and outpatient).
Patients and Methods: This study was performed on 72 patients presented by rectal bleeding, abdominal pain, consti-pation and/or chronic diarrhea between May 2015 to May 2016. They were classified into two groups: Group I included 36 patients (20 males and 16 females) presented with colorectal cancers and/or polyps diagnosed by colonoscopy and aged from 20 to 79 years. Group II included 36 patients (25 males and 11 females) without colorectal cancers or polyps screened by colonoscopy and aged from 20 to 79 years. Clinical ass-essment, laboratory evaluation, pelvi-abdominal ultrasound, CT abdomen and pelvis and colonoscopy with biopsy were carried out.
Results: In this study; the prevalence of H. pylori serop-ositivity among colorectal carcinoma or colorectal polyp patients was high and represented 70%. Also, there were non-significant relations between H. pylori antigen in stool and site of the lesion, histopathology of the lesion, type of carci-noma, grade of carcinoma, depth of invasion of carcinoma, lymph node metastasis of carcinoma and distant metastasis of carcinoma.
Conclusion: H. pylori is linked to colorectal cancers evidenced by the high prevalence of H. pylori seropositivity among colorectal carcinoma or colorectal polyp patients and produce to carcinogenic effect through the presence of bacterial byproducts and their trophic effects on colon mucosa.