Comparative Study between Dexmedetomidine, Magnesium Sulphate and Fentanyl as Sedatives in Awake Fibroptic Intubation for Patients Undergoing Cervical Spine Surgeries
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- Category: Vol. 85, June 2017
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Comparative Study between Dexmedetomidine, Magnesium Sulphate and Fentanyl as Sedatives in Awake Fibroptic Intubation for Patients Undergoing Cervical Spine Surgeries, ISLAM REDA, TAREK RADWAN, RANIA SAMIR and MOHAMMED FARID
Abstract
Background: Various drugs are used for providing favor-able intubation conditions during awake fiberoptic intubation (AFOI). However, most of them have various side effects.
Aim: The aim of this study was to compare the effects of dexmedetomedine, magnesium sulphate and fentanyl as regards sedative effects, intubation time and intubation attempts during awake fiberoptic intubation.
Material and Methods: A randomized double-blind pro-spective study was conducted on a total of 60 patients sched-uled for elective cervical spine surgeries who were randomly allocated into three equal groups (n 20): Group A patients received a bolus dose of dexmedetomidine of 1mcg/kg over 10min followed by a continuous infusion of dexmedetomidine at 0.5mcg/kg/h., Magnesium sulphate group (Group B) received dose of 30mg/kg over 10min followed by 10mg/kg/hr. and fentanyl group (Group C) received dose of 1μg/kg over 10min followed by 0.5μg/kg/hr. Ramsy Sedation score (RSS), oxygen saturation, intubation time and intubation attempts were noted and compared between three groups.
Results: RSS was significantly favorable (p<0.001) in group A in comparison to group B and C, moreover less intubation attempts was observed in group A in comparison to the other two groups.
Conclusion: Dexmedetomidine provides optimum sedation without compromising airway with favorable intubation time and less intubation attempts during AFOI in comparison to both Magnesium sulphate and fentanyl patients.