Anesthetic Adjuvant Effect of Dexmedetomedine versus Midazolam and Recovery Profile: Clinical and Electroencephalographic Study
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- Category: Vol. 85, June 2017
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Anesthetic Adjuvant Effect of Dexmedetomedine versus Midazolam and Recovery Profile: Clinical and Electroencephalographic Study, IMAN R.M. ABDEL AAL, SAHAR M. ELSHAL, HEBA I. NAGY and RAMY M. FEKRY
Abstract
Background: Many surgical procedures would not be possible without anesthesia or sedation. The goals of anesthesia or sedation are a reversible loss of consciousness with a lack of movement, a lack of awareness or recall, and unresponsive-ness to painful stimuli. Inadequate anesthesia or sedation may lead to intra operative awareness with recall or to prolonged recovery and increased risk of postoperative complications for the patients [1].
Objective: Comparing the sedative, the anesthetic adjuvant effect and the recovery profile of dexmedetomedine versus midazolam as premedicants in minor surgeries.
Patients and Method: Eighty adult patients of American society of anesthesiologists physical class I (ASA I), aged 20-50 years old, were randomly allocated into two equal groups (n=40) each patient received intravenous IV 0.04 mg/ kg midazolam (Group M) or IV 11.1g/kg dexmedetomidine (group D) over 10 minutes. Perioperative bispectral index BIS readings, sedation score and recovery times.
Results: Bispectral index BIS readings were also lower in group D than group M with high significance (p-value <0.001**) except at 60th minute intraoperative no significant difference noticed. Recovery times were shorter with high significance (p-value<0.001**) in group D than group M. No history of recall of events or intraoperative awareness were recorded in both groups.
Conflict of Interest: There is no conflict of interest
Conclusion: Dexmedetomidine was found to be a safe anesthetic adjuvant drug with superiority over midazolam, because Dexmedetomedine allows deeper anesthesia planes but with shorter recovery times in comparison to midazolam.