Determining Sevoflurane MAC Required to Achieve the Same Bispectral Index Reading in Patients Undergoing Lumbar Fixation Surgeries under Combined Sevoflurane Dexameditomidineanesthesia versus 1 MAC Sevoflurane Alone
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- Category: Vol. 85, June 2017
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Determining Sevoflurane MAC Required to Achieve the Same Bispectral Index Reading in Patients Undergoing Lumbar Fixation Surgeries under Combined Sevoflurane Dexameditomidineanesthesia versus 1 MAC Sevoflurane Alone, TAREK M. RADWAN, MOHAMMD W. AWAD, SAFINAZ H. OSMAN, HANI M. EL-KADI and MOHAMMED A. FAISAL
Abstract
Background: Dexmedetomidine is an a2-adrenegic ago-nist, with sedative, analgesic and sympatholytic propertie. It has been demonstrated that dexmedetomidine is an efficacious and safe adjuvant in general anaesthesia.
This study aimed to determine and compare different Minimal Alveolar Concentration (MAC) of sevoflurane re-quired to achieve same depth of anaesthesia measured by the Bispectral Index (BIS) in patients undergoing lumbar fixation surgeries using sevoflurane anaesthesia only versus combined sevoflurane and dexameditomidine as well as comparing recovery time and hemodynamic stability.
Patients and Methods: Patient will be randomly allocated to one of two groups using odd and even number:
•Group I (Dexmedetomidine group) (33 patients) receiving dexmedetomidine and sevoflurane.
•Group II (Control group) (33 patients) receiving sevoflurane.
Evaluated variable included mean sevoflurane concentra-tion, mean BIS values and intraoperative mean arterial blood pressure.
Results: MAC of sevoflurane of Dexmedetomidine Group was reduced by 58.1-75% compared to control group, Dexme-detomidine infusion decreased haemodynamic responses to various noxious stimuli and attenuated the emergence from anaesthesia by decreasing the immediate haemodynamic response as regard MAP, and HR.
Conclusion: We conclude that the continuous infusion of dexmedetomidine, as adjuvant in general anesthesia, signifi-cantly decreases the requirement of sevoflurane for maintaining adequate depth of anesthesia.