Hemodynamic Stability of Sedative Drugs during Awake Fibroptic Intubation for Patients Undergoing Cervical Spine Surgeries: Comparative Study
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- Category: Vol. 85, June 2017
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Hemodynamic Stability of Sedative Drugs during Awake Fibroptic Intubation for Patients Undergoing Cervical Spine Surgeries: Comparative Study, ISLAM REDA, TAREK RADWAN, RANIA SAMIR and MOHAMMED FARID
Abstract
Background: Many drugs had been used for providing favorable intubation conditions during awake fiberoptic intubation (AFOI). However, most of them associated with hemodynamic instability.
Aim: The aim of this study was to compare the effects of dexmedetomedine, magnesium sulphate and fentanyl as regards hemodynamic stability during awake fiberoptic intubation.
Material and Methods: A randomized double-blind pro-spective study was conducted on a total of 60 patients sched-uled for elective cervical spine surgeries who were randomly allocated into three equal groups (n 20): Group A patients received a bolus dose of dexmedetomidine of 1 mcg/kg over 10min followed by a continuous infusion of dexmedetomidine at 0.5mcg/kg/h., Magnesium sulphate group (Group B) received dose of 30mg/kg over 10min followed by 10mg/kg/hr. and fentanyl group (Group C) received dose of 1μg/kg over 10min followed by 0.5mg/kg/hr. Mean arterial blood pressure (MAP), heart rate (HR) and oxygen saturation were noted and compared between three groups.
Results: There was better hemodynamic stability(mean arterial blood pressure and heart rate) in group A in comparison to group B and C.
Conclusion: Dexmedetomidine provides better hemody-namic stability during AFOI in comparison to both Magnesium sulphate and fentanyl patients.