Correlation between Diffusion-Weighted Imaging and Apparent Diffusion Coefficient with Breast Cancer Biomarkers
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- Category: Vol. 85, June 2017
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Correlation between Diffusion-Weighted Imaging and Apparent Diffusion Coefficient with Breast Cancer Biomarkers, MONA E. MAREY, MAHA HELAL, ASHRAF SELIM, IMAN GOUDA, MOHAMED EL-AZAB, TALAAT HASSAAN and RANIA ZEITOUN
Abstract
Purpose: The aim of our study is to correlate the Apparent Diffusion Coefficient (ADC) value using Diffusion Weighted Imaging (DWI) with breast cancer biomarkers.
Material and Methods: 61 patients with histopathologically proved malignant breast lesions from August 2014 till April 2015 were enrolled in this study which undergoing breast Magnetic Resonance Imaging (MRI). MRI examination in-cluded T1 and T2 sequences, DWI and DCE-MRI. ADC values are correlated with the biomarkers.
Results: Mean ADC of oestrogen receptor (ER)-negative or Progesterone Receptor (PR)-negative cancer was signifi-cantly higher than that of ER-positive or PR positive cancer (p=0.00251 & p=0.00531). Mean ADC of Ki-67 index-positive cancer was significantly lower than that of Ki-67 index-negative cancer (p=0.00169). Mean ADC of HER2-positive tumours showed a statistically significant higher than mean ADC value of HER2-negative tumours (p=0.0023). The sub-type of triple negative had the highest mean ADC value (0.76 X 10–3mm2/s), compared with the other immunohistochemi-cally defined intrinsic tumour subtypes. ADC value for HER2- enriched tumours (0.72 X 10–3mm2/s) was significantly higher than that of Luminal A (0.51 X 10–3mm2/s) (p= 0.00865), and Luminal B (0.547 X 10–3mm2/s) (p=0.00965). While the difference between HER2 enriched and “triple-negative subgroup” was not statistically significant (p=00.16). Further-more mean ADC of Luminal A (0.51 X 10–3mm2/s) was insignificantly different than that of Luminal B cancer (0.547 X 10–3mm2/s) (p=0.00531).
Conclusion: Recently, various molecular techniques have been increasingly used to help refine breast cancer classification and to assess prognosis and response to therapy especially targeted therapy. ADC values vary significantly according to biological tumour features.