Effects of Monosodium Glutamate on the Kidney of Male Adult Albino Rat and the Possible Protective Role of Vitamin C
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- Category: Vol. 86, June 2018
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Effects of Monosodium Glutamate on the Kidney of Male Adult Albino Rat and the Possible Protective Role of Vitamin C, MOHAMED A. DOSUKY, DORREIA A. ZAGHLOL, SALWA M. OUIES and HANAA A. ABD EL-NAEIM
Abstract
Background: Monosodium glutamate is used commercially as a food additive and is commonly marketed as a flavour enhancer. It is now used by most fast-food chains and in many food-stuffs, in particular, processed foods. Vitamin C (ascorbic acid) is a very important and powerful antioxidant that works in aqueous environment of the body Vitamin C protects against common cold. Beneficial effects in conditions such as cancer, vascular disease, cataracts, diabetes, asthma, arthritis, Parkin-son's disease, autism and depression have also been suggested.
Aim of the Work: The aim of this study was to study the potential protective effect of Vitamin C on kidney damage caused by monosodium glutamate in adult male rats.
Material and Methods: Sixty adult albino rats were used. The animals were equally divided into three groups each of them consists of 20 rats: Group I: "Control" were given 1ml of saline daily by oral route "for one month. Group II: Were given monosodium glutamate (4gm/kg of body weight/day, dissolved in saline orally) for one month. Group III: Were given Vitamin C (500mg/kg of body weight /day, orally) then after 2 hours were given monosodium glutamate (4gm/kg of body weight/day, dissolved in saline orally) for one month.
At the end of the experiment, the rats were anaesthetized by ether then perfused with saline then with the appropriate fixator (formalin 10%). The abdomens were opened and the kidneys of the control and treated animals were extracted, cut, and processed for light and transmission electron micro-scopic studies.
Results: Monosodium Glutamate (MSG) markedly de-structed glomeruli and tubules of the kidney at light and electron microscopic examination and morphmetric studies. Administration of Vitamin C could attenuate these changes.
Conclusion: MSG caused degenerative changes in the cortical glomeruli and tubules. On the addition of Vitamin C can decrease that toxic effects of MSG.