The Value of Using Amantadine Upon Improving Conscious Level in Isolated Head Trauma Patients Guided by Glasgow Coma Scale and Bispectral Index
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- Category: Vol. 86, June 2018
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The Value of Using Amantadine Upon Improving Conscious Level in Isolated Head Trauma Patients Guided by Glasgow Coma Scale and Bispectral Index, AHMED S. SAAD, OMAR WAGIH, INAS ELSHAZLY, HISHAM ABU ELDAHAB and SAFINAZ OSMAN
Abstract
Background: We performed the current study to find out the effect of Amantadine upon rate of improvement of con-scious level in patients with isolated head injuries undergoing surgical intervention.
Aim of the Study: Finding out the value of using Amanta-dine upon improving of consciousness in head trauma patients.
Patients and Methods: Patients in group 1 (n=20) were given amantadine intraoperative at a dose of 100mg IV infusion over 3 hours, then amantadine were given at a dose of 100mg IV infusion over 3 hours every 12 hours for 7 days then was switched to tablet form at a dose of 300mg per day divided into 3 equal doses, the 1st was given in the morning and the last before 5 o'clock PM.
Patients in group 2 (n=20) were given placebo instead at the same form and intervals.
Glasgow coma scale and bispectral index readings were recorded at time of arrival, immediate post operative, 3 days and 2 weeks post operative. Results: We found that Glasgow coma scale rate of im-provement in group 1 was 4.53±2.61 and in group 2 was 2.11 ±2.81 which is statistically significant p-value 0.014.
Conclusion: We conclude from this study that the rate of improvement of patients given amantadine was significantly higher than those given placebo.