The Difference between the Therapeutic Effects of Thiamine & ACEI as Therapeutic Agents for the Control of Blood Glucose and ABP in Type II Diabetic Rats, A Comparative Study
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The Difference between the Therapeutic Effects of Thiamine & ACEI as Therapeutic Agents for the Control of Blood Glucose and ABP in Type II Diabetic Rats, A Comparative Study, MOHAMED M. KHALIFA, AKEF A. KHOWEILED, MINA J. AYAD, HANAN FOUAD and MAHMOUD R. MOHAMED
Abstract
Background: Thiamine is a vitamin with a widespread physiological functions and therapeutic effects. Its beneficial effects in different diseases conditions is the subject area of multiple recent researches. Especially in chronic diseases as diabetes and hypertension.
Aim of the Study: Test and compare the possible protective effects of angiotensin converting enzyme inhibitor and thiamine in type 2 diabetic rats.
Patients and Methods: A total of 55 male albino rats were used in this study weighing 150-200 grams. The animals were housed in wire mesh cages at room temperature, with normal light dark cycle. They were fed the commercial rat chew diet and had free access to water. These rats were divided into the following groups: Group 1: Control group, Group 2: Type 2 diabetic rats, Group 3: Type 2 diabetic nephropathy rats, Group 4: Lisinopril-treated type 2 diabetic nephropathy rats, Group 5: Thiamine mononitrate-treated type 2 diabetic neph-ropathy rats. Blood samples were collected for measurement of fasting blood glucose, fasting blood insulin. Homeostasis model assessment of insulin resistance was calculated. Systolic blood pressure and diastolic blood pressure were also measured. Nuclear factor kappa B gene expression was estimated.
Results: Treatment with angiotensin converting enzyme inhibitor reduced fasting blood glucose, fasting blood insulin, nuclear factor kappa B gene expression, systolic blood pressure and diastolic blood pressure. While treatment with thiamine mononitrate reduced fasting blood glucose and systolic blood pressure.
Conclusion: The use of angiotensin converting enzyme inhibitor and thiamine in the treatment of type 2 diabetes significantly improved the ABP and the diabetic condition in type 2 diabetes mellitus. ACE inhibitors also inhibits the inflammatory cascade.