Serum Neutrophil Gelatinase-Associated Lipocalin as a Biomarker for Early Renal Dysfunction in Adult Egyptian Patients with b-Thalassemia Major
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- Category: Vol. 86, September 2018
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Serum Neutrophil Gelatinase-Associated Lipocalin as a Biomarker for Early Renal Dysfunction in Adult Egyptian Patients with b-Thalassemia Major, NELLY D. EL-SHALL, AMAL S. EL-BENDARY, HANAA I. OKDA and KAREEM A. EL-ASHRY
Abstract
Background: Renal dysfunction in thalassemia may occur before the occurrence of any symptoms, Induction of NGAL after kidney injury precedes the elevation of classical markers for kidney damage, which made it a promising marker for renal dysfunction in b-thalassemia, major.
Aim of the Work: To assess value of serum NGAL in patients with b-thalassemia major as an early marker of renal impairment.
Patients and Methods: The present study enrolled 70 subjects and they were classified into two main groups:
•Group (I): 20 apparently healthy normal volunteers.
•Group (II): 50 multi-transfused b-thalassemia major patients.
Which subdivided according to chelation therapy into two subgroups:
•Subgroup (I): On regular iron chelation therapy.
•Subgroup (II): Without chelation therapy.
Results: In our study serum NGAL was significantly elevated in group II compared to control group. Also in our study, we found a direct correlation between NGAL and urea, creatinine, eGFR, ferritin, transferrin saturation while there was inverse correlation between NGAL and hemoglobin, b2- microglobulin.
Conclusion: NGAL could be considered as early predictor of renal dysfunction in thalassemia.