Role of Complete Blood Picture in Predicting the Etiology of Extrahepatic Cholestasis
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- Category: Vol. 86, December 2018
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Role of Complete Blood Picture in Predicting the Etiology of Extrahepatic Cholestasis, WAEL M. MORSY, ESAM A. EL-BEIH and MUHAMMAD A. EL-MASRY
Abstract
Background: Extrahepatic cholestasis is a common prob-lem worldwide and faced in daily practice however it's etiology has a wide range, before starting treatement it is mandatory to reach the cause of the disease. Investigative tools such as computerized tomography, magnetic resonance cholangiopan-creatography etc are expensive, not available in every centers, moreover their accuracy not reaching 100%.
Aim of Study: To analyse the role of complete blood count parameters namely RDW, MPV, PDW, PCT, N/L ratio, P/L ratio which are cheap and already available in 1ry care centers in assessment of extrahepatic cholestasis.
Patients and Methods: It is a cross-sectional comparative descriptive study conducted during a period of one year starting from 1/3/2016 to 28/2/2017 at Al-Rajhy Liver Hospital, Assiut University Hospitals, on patients presented with defin-itive evidence of extrahepatic cholestasis by clinical exami-nation, laboratory evidence and trans-abdominal ultrasonog-raphy.
Results: Thirty eight patients having extrahepatic cholesta-sis were included in the final analysis with a mean age of 47 years of them 14 patients were male. And 10 cases were taken as a control group of them 6 cases were male. Comparing between different etiological types of extrahepatic cholestasis as regards six parameters of the complete blood pictures namely RDW, MPV, PDW, PCT, N/L ratio, P/L ratio shows no significant differences between them. But MPV and PDW were significantly elevated in malignant distal group than control group.
Conclusion: Complete blood count parameters namely RDW, MPV, PDW, PCT, N/L ratio, P/L ratio have no significant role in the differentiation between different etiologies of extrahepatic cholestasis. But MPV and PDW were significantly elevated in malignant distal extrahepatic cholestasis than cases without hyperbilirubinemia.
Recommendation: Further studies on a larger patient's numbers is recommended.