Evaluation of Anti-Rheumatoid Arthritis Activity of White, Black Mulberry and Turmeric in Complete Freund's Adjuvant Induced Rheumatoid Arthritis Rats
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- Category: Vol. 86, December 2018
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Evaluation of Anti-Rheumatoid Arthritis Activity of White, Black Mulberry and Turmeric in Complete Freund's Adjuvant Induced Rheumatoid Arthritis Rats, SAHAR O. EL-SHAFAI, EMAD M.A. EL-KHOLIE and FATMA M.H. ABO EL-NOR
Abstract
Background: Rheumatoid arthritis (RA) is an autoimmune disorder which affects 0.5-1% of the adult population. RA affects any age group, including children, but is mostly diagnosed between the ages of 40-55 years.
Aim of Study: The aim of this investigation is to evaluate of anti-rheumatoid arthritis activity of white mulberry, black mulberry and turmeric in complete freund's adjuvant induced rheumatoid arthritis rats.
Materials and Methods: A total of 40 male albino rats weighing (140±10g) were used in this study. Rats were divided into 8 group, first group fed on basal diet as a control negative group, the second group were injected by 0. 1ml of complete fruend's adjuvant and used as a positive control group ,while the other groups were fed on basal diets blended with 5-10% of the white mulberry, black mulberry, turmeric as powder for 28 days.
Results: The results showed that turmeric, black mulberry and white mulberry record the better results in Erythrocyte Sedimentation Rate (ESR), and C reactive protein (CRP) at entry, Rheumatoid factor (RF), Anti cyclic citrullinated peptide (Anti-CCP) because of its anti-cancer, anti-inflam-matory, anti-diabetic, and anti-rheumatic properties associated with good tolerability and safety.
Conclusion: The study recommends the tested medicinal plants are useful for healing as well as for curing of human diseases because of the presence of phytochemical constituents.