The Interplay between Apelin/APJ System and Renin Angiotensin System in Protection Against Cold Restraint Stress Induced Gastric Ulcers in Adult Male Rats
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- Category: Vol. 86, December 2018
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The Interplay between Apelin/APJ System and Renin Angiotensin System in Protection Against Cold Restraint Stress Induced Gastric Ulcers in Adult Male Rats, NANCY F. SAMIR, FATMA E. IBRAHIM and LAILA A. RASHED
Abstract
Background: Activation of Renin Angiotensin System (RAS) is one of the main mechanisms involved in the devel-opment of stress induced gastric ulcers.
Aim of the Study: This study aimed to examine the effect of inhibitors of RAS in protection against stress-induced gastric ulcers and the interplay between RAS and apelin/APJ system in gastric protection.
Material and Methods: Twenty-four adult male rats were divided into 4 groups: Control, Cold Restraint Stress (CRS), Angiotensin Converting Enzyme (ACE) inhibitor + CRS and Angiotensin II receptor type 1 (AT-1) blocker + CRS. Ulcer index, PH, acidity and mucin content of gastric fluid were measured. MDA, NO, PGE2, apelin level, COX-2 and Angi-otensin 1-7 gene expression assessment were done. Gastric tissues were assessed histopathologically.
Results: Pre-treatment of rats with either capoten or micardis for 14 days prior to CRS significantly reduced ulcer index, gastric acidity, MDA and COX-2 expression; while PH, gastric acidity, mucin content, NO, PGE2, gastric apelin level and Angiotensin 1-7 gene expression were significantly elevated.
Conclusion: Our findings suggest the integration between apelin/APJ system and RAS in protection against gastric ulceration.