Clinical Applications of Monoclonal Antibodies: A Review
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- Category: Vol. 86, December 2018
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Clinical Applications of Monoclonal Antibodies: A Review
Abstract
Aim: This review explores the evolution of monoclonal antibodies (mAbs) as a pivotal component of modern therapeu-tics, detailing their pharmacological properties and applications across various diseases. Methods: A comprehensive analysis of historical advance-ments in mAb technology, production methods, and clinical applications was conducted. The review also highlights recent developments in pharmacodynamics and pharmacokinetics, underscoring the shift from traditional therapies to innovative mAb-based treatments. Results: Over the past three decades, advances in recombi-nant molecular biology have led to the successful development of over 80 mAbs targeting autoimmune diseases, cancers, and infectious diseases. Notably, mAbs demonstrate high specific-ity and affinity for their targets, which minimizes off-target ef-fects and enhances therapeutic efficacy. The review discusses various mechanisms of action, including immune modulation and direct tumor targeting, alongside the pharmacokinetic ad-vantages of mAbs, such as prolonged circulation and targeted delivery. Conclusion: The transformation of therapeutic modalities through mAbs signifies a remarkable advancement in personal-ized medicine. Future research should focus on expanding the spectrum of mAb applications, optimizing pharmacological properties, and minimizing immunogenicity to enhance patient outcomes.