Association of Ki-67 Expression and the Aggressiveness of Hepatocellular Carcinoma
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- Category: Vol. 87, June 2019
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Association of Ki-67 Expression and the Aggressiveness of Hepatocellular Carcinoma, WALAA G. EL-GENDY, NANIS S. HOLAH, DALIA R. EL-SHARAKY, DINA S. EL-AZAB, ASMAA G. ABDOU and MOHAMMED T. BADR
Abstract
Background: Ki-67 is a nuclear proliferative marker. It is therefore widely used as a cell proliferation marker to grade tumors.
Aim of Study: The aim of the current study was to assess the possible association between Ki-67 and the aggressiveness of hepatocellular carcinoma.
Material and Methods: This study was conducted at Pathology Department in National Liver Institute, Menoufia University. A total of 114 cases were included. TMA was performed for tumor blocks and stained with antibody against Ki-67.
Results: The percentage of Ki-67 expression ranged between 1 and 95% with a mean ± SD of 56.72±40.53 and a median of 80. As regard Ki-67 expression, large tumor size group were significantly associated with increased expression of Ki-67 (p=0.049). On the other hand, older age group (>60 years) and large tumor size group (>5cm) were significantly associated with increased percentage of Ki-67 expression (p=0.035 and 0.015) respectively.
Conclusion: Ki-67 expression is associated with aggressive hepatocellular carcinoma, so it could change the type of therapy for these tumors.