Effect of Vitamin D Supplementation on Ovulation among Women with PCO
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- Category: Vol. 88, December 2020
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Effect of Vitamin D Supplementation on Ovulation among Women with PCO, AHLAM NASIR ABOUD AL HAYANI
Abstract
Background: Polycystic Ovarian Syndrome (PCOS) is prevalent worldwide among female endocrine disorder, affect-ing nearly 5% to 12% of child bearing age women. PCOS is considered as the most common cause of an ovulatory infertility and it has clinical symptoms include an ovulation with or without oligo-ovulation, infertility, menstrual irregularity, polycystic ovaries and hyperandrogenism. Aim of Study: This study aim was to explore and compare the effects of Vitamin D supplementation vs. placebo on ovulation in women with PCOS. Patients and Methods: 400 women with PCOSwere in-cluded in this randomized controlled trial. Patients were randomly allocated into 2 groups as follows: Vitamin D group (n=200) and control group (n=200). Follow-up was done after three months by measuring change vitamin D level, change in insulin resistance as measured by fasting glucose and fasting insulin ratio, change in testosterone level, and change in free androgen index. Results: 200 of them allocated to control group. Among 200 women in vitamin D group, 160 women had vitamin D deficiency and the other 40 had normal vitamin D level. FBS, fasting insulin and HOMA-IR were statistically significantly higher in the vitamin D deficient subgroup and the control group compared to the normal vitamin D subgroups; whereas no statistically significant differences were found between the vitamin D deficient subgroup and the control group. No statistically significant differences were found between the three groups in the various components of the lipid profile and hormonal profile. There were statistically significant differences between groups as regards FBS, fasting insulin, HOMA-IR, FAI, Testosterone, TC and LDL-C. Conclusion: We concluded that vitamin D seems to be a contributing etiopathogenic factor in anovulatory, metabolic and hormonal aberrations in women with PCOS that might have a potential adjuvant role to standard induction of ovulation regimen.