Prognostic Value of PET/CT and ALDH1 in Pancreatic Cancer and Correlation of Standardized Uptake Values with Clinical Characteristics and Survival
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- Category: Vol. 88, June 2020
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Prognostic Value of PET/CT and ALDH1 in Pancreatic Cancer and Correlation of Standardized Uptake Values with Clinical Characteristics and Survival, DINA MOGHAZY MOHAMED, DAREEN ABDULAZIZ and RANIA SOBHY ABOUKHADRAH
Abstract
Background: Pancreatic malignancy is a rapidly growing cause of death in the world. Its survival rate is months even if discovered early. Aim of Study: We evaluated the correlations between PET/SUVs (Standard Uptake Values), clinical characteristics and cancer stem-like cells named aldehyde dehydrogenase 1 (ALDH1) in pancreatic cancer. We evaluated the diagnostic performance of SUV and its correlation with overall survival. Patients and Methods: Thirty-nine patients with pancreatic cancer were evaluated by PET/CT. The expression of ALDH1 was detected immunohistochemically in their cancer speci-mens. Results of PET/SUV were correlated with clinic-pathological character, ALDH1 and overall survival. Results: PET/SUV was associated significantly with tumor size (p=0.027). No significant correlation with other clinical-pathological characteristics. PET/CT showed sensitivity= 81%, specificity=78% and accuracy=82%. PET/SUV reflected the expression level of ALDH1 with significant correlation (p=0.001). Patients with high SUV and high expression of ALDH1 had a worse median overall. Conclusion: PET-CT was a non-invasive imaging modality that helped in pancreatic cancer especially in doubtful tumors. PET/CT was helpful tool to detect lymph nodes invasion and distant metastasis. It was associated with the expression level of ALDH1. High SUV and high expression of ALDH1were significantly correlated with a worse clinical outcome. PET/SUV and Cancer stem cells may serve as significant prognostic factors in predicting outcomes in pancreatic cancer patients.