A Study on the Effect of Glucagon Like Peptide 1 Agonist on Glycemic State, Renal Functions and Some Hemodynamic Parameters in Diabetic Male Albino Rats
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- Category: Vol. 88, March 2020
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A Study on the Effect of Glucagon Like Peptide 1 Agonist on Glycemic State, Renal Functions and Some Hemodynamic Parameters in Diabetic Male Albino Rats, SOHEIR A. SALEH, SHAIMAA M. MOTAWEA, AHMAD M. GAFFER, ALSHAIMAA E. MOHAMED and SUZY F. EWIDA
Abstract
Background: Vascular and renal complications are com-mon associations to diabetes mellites despite current therapies. Glucagon like peptide 1 may present a recent solution to these complications and provide a better control. Aim of Study: This investigation aimed to study the effects of glucagon like peptide 1 receptor agonist on induced type 2 diabetes mellitus and the possible underlying mechanisms. Methods: Fifty male albino rats classified into five groups, 10 rats each: Non diabetic, diabetic non treated, diabetic metformin-treated, exendin-4 treated diabetic and combined metformin & exendine-4 treated diabetic groups. After 7 weeks, systolic blood pressure, renal blood flow and renal resistance were measured. Urine volume per minute, urine creatinine, creatinine clearance, fasting blood glucose, glyc-osylated hemoglobin (HbA1c %), serum insulin, serum glu-cagon, blood urea nitrogen, total anti-oxidant capacity, serum malondialdehyde (MDA) and serum tumor necrosis factor alpha (TNFa) were assessed. Results: The diabetic metformin, exendine-4-and combined metformin & exendine-4-treated groups revealed significant improvement in glycemic state, oxidative stress, inflammatory state, hemodynamic parameters and renal functions compared to the corresponding values of diabetic non-treated group. Exendin-treated group significantly decreased the previously mentioned parameters plus glucagon level compared to diabetic non-treated and diabetic metformin-treated groups. Combined metformin & exendine-4-treated group showed improvement of all previously mentioned parameters more than each treat-ment alone. Conclusion: Exendine-4 treatment improved diabetic parameters and associated hemodynamic and renal complica-tions more effective than that of the specific agents as met-formin. Combined metformin treatment with exendine-4 showed significant improvement than that of using each of them alone.