Human b-2 Defensin in Tinea Versicolor and Tinea Circinata
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- Category: Vol. 89, June 2021
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Human b-2 Defensin in Tinea Versicolor and Tinea Circinata, AMR A. RATEB, AMIRA M. EL TAWDY, FAISAL NOUR EL DIN, RANA ABD ELAZEEM HAMMAD, KHALDA S. MOHAMED and DINA M. SALAMA
Abstract
Background: Both superficial tinea and pityriasis versicolor are very popular fungal skin infections that affect people all over the world. Recent research suggests that certain antimi-crobial peptides can also play a role in the body's natural defense against fungal infection. Aim of Study: The purpose of the current research would be to investigate the tissue expression of b2-defensin mRNA in lesions of tinea versicolor and lesions of tinea circinata and hence studying its role in fungal infection pathogenesis. Patients and Methods: Twenty patients with tinea versi-color, twenty with tinea circinata, and twenty controls were included in this case control study. For real-time PCR (RT-PCR) gene expression of b2-defensin mRNA, a punch skin biopsy was obtained from the patient's lesional and non-lesional skin, as well as normal skin from a control. Results: b2 defensin was upregulated in lesional areas of tinea versicolor and tinea circinata in comparison to non lesional areas of tinea versicolor, tinea circinata and control. These results reached a statistical significance for mRNA b2 defensin in tinea versicolor and tinea circinata (p-value <0.014). Conclusion: The results back up the theory that antimi-crobial peptides (b2-Defensin) may help the skin fight der-matophytes and M. furfur.