Diagnostic Performance of Multiparametric MRI in Characterizing Adrenal Lesions
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- Category: Vol. 92, June 2024
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Diagnostic Performance of Multiparametric MRI in Characterizing Adrenal Lesions, MOHAMMED FARAGALLA, MAGDA EL-BAKRY, TAREK EL-DIASTY, SAMIA ZAKI and NEHAL THARWAT
Background: Adrenal nodules are common incidental find-ings in radiological daily routine with lipid-rich adenomas are the most frequent. Sometimes lipid-poor adenomas may not be fully characterized on CT or chemical shift imaging (CSI). These indeterminate lesions pose management dilemmas par-ticularly in patients with known primary malignancy. Aim of Study: The aim of this study was to evaluate the di-agnostic performance of mutliparametric MRI in characteriza-tion of adrenal lesions, with particular regard to the distinction between adenomasand malignant tumors. Material and Methods: Forty patients with 42 adrenal le-sions underwent multiparametric MRI including conventional MRI, CSI, diffusion weighted imaging (DWI), diffusion tensor imaging (DTI, in 12 patients) and dynamic contrast enhanced (DCE) MRI. Imaging features on conventional MRI were eval-uated, CSI was assessed both qualitatively and quantitatively by calculating the adrenal signal intensity index (ASII), appar-ent diffusion coefficient (ADC) and fractional anisotropy (FA) values of the lesions were measured and enhancement pattern on DCE-MRI was assessed both qualitatively and quantitative-ly. Statistical analysis was performed. Results: Most adenomas displayediso- to low signal inten-sity (SI) on T2-weighted images (WI), while most non-adeno-mas exhibited heterogeneous high T2-SI.A significant signal drop on CSI was seen in most of adenomas. ASII exhibited high statistically significant difference (p=0.01) in differentiating ad-enomas from non-adenomas, at acut off value of 23% the sen-sitivity was 92% and the specificity was78%. On DWI, ADC valuescould not show significant statistical difference between adenomas and non-adenomas. On the other hand, FA values measured on DTI revealed high statistically significant differ-ence in differentiating adenomas from non-adenomas (p=0.01). In receiver operating characteristics (ROC) curve analysis, FA cut off value 0.34 gave 100% sensitivity and 84% specificity. As regard DCE-MRI, most adenomas exhibited homogeneous enhancement, whereas most adrenocortical carcinomas (ACC) and metastases showed heterogeneous or peripheral enhance-ment. Quantitative assessment of dynamic curve including time to peak (TTP) enhancement showed high statistically signifi-cant difference in differentiating adenomas from non-adenomas (p=0.01), a cut off value 43 seconds gave 100% sensitivity and 60% specificity. Conclusions: Multiparametric MRI including convention-al imaging, CSI, DWI, DTI as well as DCE-MRI is helpful in characterizing adrenal lesions with increased diagnostic confi-dence.