Role of Macrophage Migration Inhibitory Factor in Prediction of Cardiac Affection in Multisystem Inflammatory Syndrome in Children
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- Category: Vol. 92, September 2024
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Role of Macrophage Migration Inhibitory Factor in Prediction of Cardiac Affection in Multisystem Inflammatory Syndrome in Children, ABDELRAHMAN M.A. FARAG, ALYAA A. KOTBY, NEHAD A. BAKRY, LAMYAA SALEM and EMAN M. EL SAYED
Abstract
Background: Multisystem inflammatory syndrome in chil-dren (MIS-C) is a dysregulated immune response to viral infec-tion by COVID-19 accompanied by systemic manifestations. Macrophage migration inhibitory factor (MIF) exerts inhibitory effects on macrophage migration and is raised in adult cardiac critical illness Aim of Study: To identify the role of MIF as a marker of cardiac affection in MIS-C patients. Patients and Methods: This case-controlled study was con-ducted on 24 MIS-C children and 24 apparently healthy con-trols. Clinical and laboratory data were compared between both groups. Echocardiography was done for all participants. Results: Myocardial injury markers as troponins, CK-MB and liver injury markers were significantly (p>0.05) elevated among MIS-C patients than controls. MIF expression was also significantly higher (p>0.05) among MIS-C patients. Impaired LV function and valve regurgitation were the main echocardio-graphic findings among MIS-C patients. MIF correlated sig-nificantly with age, lymphocytic count, ferritin, LDH, D-dimer, CK-MB, EF%, LVESD, LVEDD, Z-score RCA and Z-score LCA. Conclusion: Myocardial injury is common in MIS-C pa-tients. Impaired LV function is the most prominent echocardio-graphic finding. MIF could be considered as a biomarker for MIS-C and correlated significantly with myocardial affection among those patients.