Protective Effect of Lepidium Sativum Seeds and Captopril Against Cisplatin-Induced Hepato-Cardio Toxicity in Rats
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- Category: Vol. 92, December 2024
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Protective Effect of Lepidium Sativum Seeds and Captopril Against Cisplatin-Induced Hepato-Cardio Toxicity in Rats, SHAWKIA S. ABDEL-HALIM, AMAL H. EMARA and HODA M. EL-GEZERY
Abstract Background: Cisplatin (Cis) is one of the most potent chemotherapeutic antitumor drugs. The therapeutic efficacy of Cis is limited by its severe side effects comprising kidneys heart and liver toxicity Lepidium sativum seeds (LSS) (family: Cruciferae) has been used in traditional medicine for the treat-ment of jaundice, liver problems, spleen diseases and gastroin-testinal disorders. Aim of Study: The aim of this study is to investigate the hepato-cardio protective effects of Lepidium sativum seedsex-tract. (LSSE) and/or Captopril (Cap) on Cis-intoxicated rats. Material and Methods: Seventy adult male albino rats were used, they were fed rodent chow diet for 14 days (experimen-tal period). Rats were categorized in 7 groups (10 rat/group). Group 1, normal control, intraperitoneally injected with 2ml sa-line solution at day 10 of experiment. Group 2, received a sin-gle intraperitoneal injection of 7.5mg/kg BW Cis at day 10 of experiment. Group 3, orally administered 60 mg/kg B.W cap-topril for 14 days with the same course of Cis-injection. Group 4 and 5 received oral administration of 200 and 400mg/kg B.W LSSE respectively along with the same course of Cis-injection. Group 6 and 7 received oral administration of 200 and 400 mg/ kg B.W LSSE with 60mg Cap, along with the same course of Cis-injection. Results: Cis-toxicity were evidenced by significant increase in malondialdehyde, MDA (as an index of lipid peroxidation) and in serum levels of hepatic enzymes and lactate dehydroge-nase, LDH as well as in pro-inflammatory markers tumor ne-crosis factor α (TNF-α) and interlukin-6 (IL-6). However, the levels of glutathione (GSH) and Copper and zinc superoxide dismutase (Cu/Zn SOD) were decrease. Concurrent administra-tion of LSSE and/or Cap attenuated-induced Cis-disturbances in liver and heart enzymes as Concurrent administration of well as oxidative status, and pro-inflammatory cytokine. Conclusion: LSSE and Cap appear to be potent candidates to ameliorate hepatic and cardiac toxicity associated with Cis toxicity in rats.