The Effect of Different Doses of Finasteride on Epididymis and Testosterone and DHT Concentrations in Rats
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- Category: Vol. 77, September 2009
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The Effect of Different Doses of Finasteride on Epididymis and Testosterone and DHT Concentrations in Rats, CHERRY N.K. SERGA
Abstract
Objective: Finasteride is a widely used in the treatment of alopecia and prostatic hyperplasia. Our study was conducted to assess the effect of different doses of Finasteride on epid-idymis, testosterone and dihydrotestosterone concentrations in male Sprague-Dawley rats.
Design, Material and Methods: This is experimental study conducted where thirty male rats are divided into three groups (10 rats in each group); high dose, low dose and control groups. During 2 months period, testosterone and DHT were being measured and at the end of the experiment, rats were killed by cervical dislocation. Weight of the organs and histopathological examination were done.
Results: DHT was found significantly reduced by finas-teride administation. Testosterone was unexpectedly reduced in our study. Reduction in glandular epithelium and stromal component was clearly evident in histopathological examina-tion of the prostate. Weights of seminal vesicles, dorsal prostate and ventral prostate were significantly decreased with finas-teride administration. Sperm count and motility were not significantly changed in low-dose finasteride-treated group but there was a significant reduction in sperm counts and motility in high-dose group.
In Conclusion: Finasteride has significant effects on testosterone, DHT. Also, it can affect epididymal functions if administered in high dose. It is evident from our results that there is a need for further clarification of the relation between finasteride administration and specific parameters in epididymal functions.