The Effect of Different Doses of Finasteride on Sperm Morphology and Motility and Reactive Oxygen Species Concentrations in Rats
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- Category: Vol. 77, September 2009
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The Effect of Different Doses of Finasteride on Sperm Morphology and Motility and Reactive Oxygen Species Concentrations in Rats, CHERRY N.K. SERGA
Abstract
Objective: Finasteride is a widely used in the treatment of alopecia and prostatic hyperplasia. Our study was conducted to assess the effect of different doses of Finasteride on sperm morphology and motility and Reactive Oxygen Species ROS concentrations in male Sprague-Dawley rats.
Design, Material and Methods: This is experimental study conducted where thirty male rats are divided into three groups (10 rats in each group); high dose, low dose and control groups. During 2 months period, Glutathione assay was done in the prepared blood samples the end of the experiment; rats were killed by cervical dislocation. Sperm counts and mor-phology were assessed.
Results: Glutathione were found to be decreased signifi-cantly with increasing dose of administered finasteride which indicate statistically significant increase in the ROS levels. On the other hand, sperm motility was negatively affected only in high dose group. Abnormal sperm forms were also significant in the high-dose group. Sperm motility and mor-phology were not significantly changed in low-dose finasteride-treated group.
In Conclusion: Finasteride has significant effects on ROS production. Also, it can affect sperm motility and morphology negatively in high doses. Further studies clarifying the exact site and mechanism of action underlying the effects of 5 alpha-reductase inhibition on spermatogenesis are needed.