The Value of IL10, RANTES and Antithrombin in Prediction of Sepsis Induced DIC in Preterm Infants
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- Category: Vol. 78, March 2010
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The Value of IL10, RANTES and Antithrombin in Prediction of Sepsis Induced DIC in Preterm Infants, HANAN F. MOHAMAD and MOHAMAD H. SALAH
Abstract
Late onset bacterial infection and DIC and/or septic shock in preterm very low birth weight infants carry a high risk of morbidity and mortality. The progression to DIC in infected very low birth weight infants is difficult to predict at the onset of sepsis. We investigated the levels of IL10, RANTES and Antithrombin and the usefulness of their measurement to predict the development of sepsis induced DIC at onset of clinical presentation of infection. We investigated 60 infants with clinical signs and symptoms of sepsis, of which 22 were proven blood culture positive (group 1), 18 were clinically infected culture negative (group 2) and 20 non infected served as control group (group 3).
IL10 showed a significant up reglation in group 1 com-pared to group 2&3 and in the subgroup who developed DIC while RANTES and Antithrombin showed significant down regulation.
Our model which consisted of simultaneous measurement of IL10, RANTES and Antithrombin showed that IL10 at level >1400pg/ml, RANTES at level <2850pg/ml and Anti-thrombin at concentration <13.2mg/dl could sensitively and reliably predicted the development of all DIC patients in septic infants at onset of clinical presentation without misdi-agnoses of non DIC cases. This information could be vital for early and effective treatment of neonatal sepsis.