Endostatin, VEGF and VEGFR in Broncho Alveolar Lavage in Egyptian Patients with Idiopathic Pulmonary Fibrosis and Pulmonary Sarcoidosis
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- Category: Vol. 79, September 2011
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Endostatin, VEGF and VEGFR in Broncho Alveolar Lavage in Egyptian Patients with Idiopathic Pulmonary Fibrosis and Pulmonary Sarcoidosis HODA EL RAWI, M.D. ; KHALED M. KAMEL, M.D. and LILA A. RASHED, M.D.
Abstract
Idiopathic pulmonary fibrosis (IPF) encompasses a dis-tinctive subgroup of interstitial pneumonias associated with substantial pulmonary fibrosis for which the cause is obscure. Sarcoidosis is a systemic granulomatous disorder that com-monly affects the lungs.
Aim of the Work: This study aimed to investigate the role of Endostatin and VEGF in idiopathic pulmonary fibrosis and sarcoidosis and their relation to degree of pulmonary fibrosis.
Subjects and Methods: The study was carried on 10 cases with IPF, 10 cases with sarcoidosis and 10 control cases.
All patients were subjected for the following: Complete history taking and clinical examination, Chest X-rays PA and lateral views, Chest CT scan, Arterial blood gases, Fiberoptic bronchoscope study, bronchoalveolar lavage and transbronchial lung biopsies and Analysis of bronchoalveolar lavage fluid (BALF) for Endostatin and VEGF & VEGFR.
Results: BALF Endostatin WAS significantly higher in cases with IPF and cases with Sarcoidosis in comparison to control cases while both VEGF & VEGFR exepression WERE significantly lower in patients than control p-value <0.005. BALF Endostatin was significantly higher in cases with IPF in comparison to cases with Sarcoidosis. BALF Endostatin was correlated with pulmonary fibrosis and level of PaO2. Conclusion: Endostatin and VEGF BALF have role in the pathogenesis of lung injury in cases with IPF and Sarcoidosis.