Association between Non Alcoholic Fatty Liver Disease and Early Carotid Atherosclerosis
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- Category: Vol. 80, March 2012
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Association between Non Alcoholic Fatty Liver Disease and Early Carotid Atherosclerosis, BAHAA EL-DIN ZAYED, SHERIF SARIE EL-DIN and EMAD EL-MOOATISM
Abstract
Background and Aim of the Work: The increasing rate of morbidity and mortality from cardiovascular disease are probably among the most important clinical features associated with NAFLD. Recent cross-sectional studies have shown that NAFLD is associated with increased carotid artery intima-media thickness (IMT), a marker of early generalized athero-sclerosis. We have, therefore, assessed whether patients with NAFLD with normal LDL have a greater carotid IMT than control subjects.
Material and Methods: 70 patients and 30 controls in-cluded in the study with history intake and clinical examination for: BP, BMI, waist circumference, Abdominal U/S, liver function tests, serology for Hepatitis B and C, lipid profile, FBG and carotid duplex.
Results: The study group included seventy (70) patients; their mean age was 41.0±5.5 years. Thirty three males (47.1 %) and thirty seven females (52.9%). The mean BMI was 22.5± 0.3Kg/m2, the mean waist circumference was 74.9±4.1cm, mean FBG was 85.3±7.4mg/dl, mean PT was 12.5±0.7sec, the mean of the serum albumin was 3.4±0.3 (g/dl). They had fatty liver by U/S which was categorized into mild, moderate, and severe. There was statistically significant difference in liver enzymes, synthetic liver function tests between the study and the control groups mean. Carotid IMT in control subjects was 0.6±0.03mm, in the study group was 0.8±0.1mm. with statistically significant difference, also comparing the carotid intima-medial thickness in the three subgroups of the study group according to the degree of fatty infiltration (mild, moderate, and severe) it was found that the mean carotid IMT thickness in mild group was 0.8±0.2mm, moderate group was 0.9± 0.01mm and severe group was 0.9±0.01mm (p=0.0001).
Conclusion: NAFLD is strongly associated with early carotid atherosclerosis, the degree of fatty infiltration add another risk factor for incidence of early carotid atherosclerosis as a marker for early generalized atherosclerosis.