Alteration of Hematological and Plasma Physiological Parameters Following a Standard Protocol of General Anesthesia: A Pilot Study in Assiut University Hospitals
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- Category: Vol. 81, December 2013
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Alteration of Hematological and Plasma Physiological Parameters Following a Standard Protocol of General Anesthesia: A Pilot Study in Assiut University Hospitals, NERMIEN WALY, WALEED S.H. FARRAG and ASHRAF HASABALLA
Abstract
The objective of this study was to evaluate the effects of a standard anesthetic protocol using Propofol, fentanyl, and Sevoflourane, on hematological and plasma physiological variables in humans. Blood samples were collected from fourteen (14) individuals undergoing surgery for a complete blood count (CBC) before and after the induction of anesthesia. Plasma physiological parameters as creatinine, urea, and blood glucose level were also measured.
Hemoglobin concentration, showed a significant decrease after anesthesia induction (p<0.0001). There was also a significant decrease in the red blood cell (RBC’s) count and hematocrit values (p<0.001 & p<0.05 respectively). Total leucocytic count (TLC) and platelets exhibited a non-significant reduction. Serum creatinine significantly reduced (p<0.0001) after the induction of anesthesia while blood urea significantly increased (p<0.001). There was a non-significant increase in blood glucose level.
This study suggests that a careful monitoring during anesthesia is advisable to avoid possible postoperative life threatening complications.