Immunohistochemical Expression of Toll-Like Receptor 3 in Verruca Vulgaris
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- Category: Vol. 81, December 2013
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Immunohistochemical Expression of Toll-Like Receptor 3 in Verruca Vulgaris, AHMED A. SALEH, FATMA M. EL-ESAWY and TAGHREED A. ABDEL AZIZ
Abstract
Background: Toll-like receptors are expressed on both immune and nonimmune cells and respond to specific com-ponents of microbial pathogens, their signaling results in the activation of nuclear factor B (NF-B), which triggers the production of a variety of antimicrobial and proinflammatory cytokines and chemokines.
Objective: The purpose of this study was to evaluate the role of Toll-like receptors 3 (TLR 3) in the pathogenesis of verruca vulgaris (VV) by its immnohistochemical expression in the skin lesions of VV patients.
Patients and Methods: This study was carried out on 20 patients with verruca vulgaris and 20 apparently healthy volunteers served as controls. All patients and controls were presenting at Benha Dermatology Department's Outpatients Clinic. A written consent was taken from each patient and control before participation in the study. This study was carried out during the period between March 2012 to February 2013. A 4mm punch skin biopsies were taken from wart in patient group and from normal skin in control group for histopatho-logical staining and immnohistochemical staining of TLR 3.
Results: There was a highly significant increase (p<0.001) in the TLR3 expression, density and staining intensity in all cases as compared with the normal controls.
Conclusion: Epidermal TLR3 may have an important role in cutaneous innate immune responses to cutaneous human papillomavirus infections. So, Toll-like receptor agonists represent a promising approach for the treatment of verruca vulgaris.